Selected Publications:
Klunk, J*, Vilgalys TP*, Demeure CE, Cheng X, Shiratori, M, Madej J, Beau R, Elli D, Patine, MI, Redfern R, DeQitte SN, Gamble JA, Boldsen JL, Carmichael A, Varlik N, Eaton K, Grenier JC, Golding GB, Devault A, Rouillard JM, Yotova V, Sindeaux E, Ye CJ, Bikaran M, Dumaine A, Brinkworth J, Missiakas D, Rouleau G, Steinrucken M, Pizarro-Cerda J, Poinar HN, Barreiro LB (2022) Evolution of immune genes is associated with the Black Death. Nature – Nature
Randolph HE, Fiege JK, Thielen BK, Mickelson CK, Shiratori M, Barroso-Batista J, Langlois RA, Barreiro LB. (2021) Genetic ancestry effects on the response to viral infection are pervasive but cell type specific. Science. – Science
Genelle F Harrison, Joaquin Sanz, Jonathan Boulais, Michael J Mina, Jean-Christophe Grenier, Yumei Leng, Anne Dumaine, Vania Yotova, Christina M Bergey, Stephen J Elledge, Erwin Schurr, Lluis Quitana-Murci, George H Perry, Luis B Barreiro (2019) Natural selection contributed to immunological differences between human hunter-gatherers and agriculturalists. Nat. Ecol. Evol. – Nat. Ecol. Evol.
Alain Pacis, Florence Mailhot-Leonard, Ludovic Tailleux, Haley E. Randolph, Vanya Yotova, Anne Dumaine, Jean-Christophe Grenier, Luis B. Barreiro (2018) Gene activation precedes DNA methylation in response to infection in human dendritic cells. Proc. Natl. Acad. Sci. U.S.A. – Proc. Natl. Acad. Sci
Eva Kaufmann, Joaquin Sanz, Jonathan L. Dunn, Nargis Khan, Laura E. Mendonça, Alain Pacis, Fanny Tzelepis, Erwan Pernet, Anne Dumaine, Jean-Christophe Grenier, Florence Mailhot-Léonard, Eisha Ahmed, Jad Belle, Rickvinder Besla, Bruce Mazer, Irah L. King, Anastasia Nijnik, Clinton S. Robbins, Luis B. Barreiro and Maziar Divangahi (2018) BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis. Cell – Cell
Snyder-Mackler N, Sanz J, Kohn JN, Brinkworth JF, Morrow S, Shaver AO, Grenier JC, Pique-Regi R, Johnson ZP, Wilson ME, Barreiro LB, Tung J. (2016) Social status alters immune regulation and response to infection in macaques. Science – Science
Nédélec Y, Sanz J, Baharian G, Szpiech ZA, Pacis A, Dumaine A, Grenier JC, Freiman A, Sams AJ, Hebert S, Pagé Sabourin A, Luca F, Blekhman R, Hernandez RD, Pique-Regi R, Tung J, Yotova V, Barreiro LB. (2016) Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens. Cell – Cell
Pre-prints
Aracena AK, Lin Y-L, Luo K, Pacis A, Gona S, Mu Z, Yotova V, Sindeaux R, Pramatarova A, Simon M-M, Chen X, Groza C, Lougheed D, Gregoire R, Brownlee D, Li Y, He X, Bujold D, Pastinen T, Bourque G, Barreiro LB. Epigenetic variation impacts ancestry-associated differences in the transcriptional response to influenza infection. (2022) bioRxiv – bioRxiv
2023
Sun S, Aguirre-GamboaR, Barreiro LB (2023) Transmission of stimulus-induced epigenetic changes through cell division is coupled to continuous transcription factor activity. Front Immunol. – Front Immunol
Groza C, Chen X, Pacis A, Simon MM, Pramatarova A, Aracena AK, Pastinen T, Barreiro LB, Bourque B. (2023) Genome graphs detect human polymorphisms in active epigenomic state during influenza infection. Cell Genomics – Cell Genomics
Chen X, Pacis A, Aracena AK, Gona S, Kwan T, Groza C, Lin Y-L, Sindeaux R, Yotova V, Pramatarova A, Simon MM, Pastinen T, Barreiro LB, Bourque G (2023) Transposable elements are associated with the variable response to influenza infection. Cell Genomics – Cell Genomics
Mendonca LE, Pernet E, Khan N, Sanz J, Kaufmann E, Downey J, Grant A, Orlova M, Schurr E, Krawczyk C, Jones RG, Barreiro LB, Divangahi M. (2023) Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection. Front Immunol. – Front Immunology
Earley ZM, Lisicka W, Sifakis JJ, Aguirre-Gamboa R, Kowalczyk A, Barlow JT, Shaw DG, Discepolo V, Tan IL, Gona S, Ernest JD, Matzinger P, Barreiro LB, Morgun A, Bendelac A, Ismagilov RF, Shulzhenko N, Riesenfeld SJ, Jabri B. (2023) GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology. Immunity – Immunity
Pernet E, Sun S, Sarden N, Gona S, Nguyen A, Khan N, Mawhinney M, Tran KA, Chronopoulos J, Amberkar D, Sadeghi M, Grant A, Wali S, Prevel R, Ding J, Martin JG, Thanabalasuriar A, Yipp BG, Barreiro LB, Divangahi M. (2023) Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE. Nature – Nature
2022
Klunk, J*, Vilgalys TP*, Demeure CE, Cheng X, Shiratori, M, Madej J, Beau R, Elli D, Patine, MI, Redfern R, DeQitte SN, Gamble JA, Boldsen JL, Carmichael A, Varlik N, Eaton K, Grenier JC, Golding GB, Devault A, Rouillard JM, Yotova V, Sindeaux E, Ye CJ, Bikaran M, Dumaine A, Brinkworth J, Missiakas D, Rouleau G, Steinrucken M, Pizarro-Cerda J, Poinar HN, Barreiro LB (2022) Evolution of immune genes is associated with the Black Death. Nature – Nature
Labrosse R, Boufaied I, Bourdin B, Gona S, Randolph HE, Logan BR, Bourbonnais S, Berthe C, Chan W, Buckley RH, Parrott RE, Cuvelier GDE, Kapoor N, Chandra S, Dávila Saldaña BJ, Eissa H, Goldman FD, Heimall J, O’Reilly R, Chaudhury S, Kolb EA, Shenoy S, Griffith LM, Pulsipher M, Kohn DB, Notarangelo LD, Pai SY, Cowan MJ, Dvorak CC, Haddad É, Puck JM, Barreiro LB, Decaluwe H. (2022) Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation. J Allergy Clin Immuno – J Allergy Clin Immunology
Downey J, Randolph HE, Pernet E, Tran KA, Khader SA, King IL, Barreiro LB, Divangahi M. (2022) Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus. Cell Rep. – Cell Reports
Björk JR, Dasari MR, Roche K, Grieneisen L, Gould TJ, Grenier JC, Yotova V, Gottel N, Jansen D, Gesquiere LR, Gordon JB, Learn NH, Wango TL, Mututua RS, Kinyua Warutere J, Siodi L, Mukherjee S, Barreiro LB, Alberts SC, Gilbert JA, Tung J, Blekhman R, Archie EA. (2022) Synchrony and idiosyncrasy in the gut microbiome of wild baboons. Nat Ecol Evol. – Nat Ecol. Evol
Kaufmann E, Landekic M, Downey J, Chronopoulos J, Teimouri Nezhad S, Tran K, Vinh DC, Barreiro LB#, Divangahi M#. (2022) Lack of evidence for intergenerational inheritance of immune resistance to infections. Nat Immunology – Nat Immunology #co-corresponding authors
Simons ND, Michopoulos V, Wilson M, Barreiro LB, Tung J. (2022) Agonism and grooming behaviour explain social status effects on physiology and gene regulation in rhesus macaques. Philos Trans R Soc Lond B Biol Sci. – Philos Trans R Soc London B Biol Sci
2021
Rogers D, Sood A, Wang H, van Beek JJP, Rademaker TJ, Artusa P, Schneider C, Shen C, Wong DC, Bhagrath A, Lebel MÈ, Condotta SA, Richer MJ, Martins AJ, Tsang JS, Barreiro LB, François P, Langlais D, Melichar HJ, Textor J, Mandl JN.(2021) Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential. Cell Rep. – Cell Rep
Randolph HE, Fiege JK, Thielen BK, Mickelson CK, Shiratori M, Barroso-Batista J, Langlois RA, Barreiro LB. (2021) Genetic ancestry effects on the response to viral infection are pervasive but cell type specific. Science. – Science
Correa-Macedo W, Fava VM, Orlova M, Cassart P, Olivenstein R, Sanz J, Xu YZ, Dumaine A, Sindeaux RH, Yotova V, Pacis A, Girouard J, Kalsdorf B, Lange C, Routy JP, Barreiro LB, Schurr E. (2021) Alveolar macrophages from persons living with HIV show impaired epigenetic response to Mycobacterium tuberculosis. J Clin Invest. – J Clin Invest
Mayassi T, Barreiro LB, Rossjohn J, Jabri B. (2021) A multilayered immune system through the lens of unconventional T cells. Nature. – Nature
Das S, Marin ND, Esaulova E, Ahmed M, Swain A, Rosa BA, Mitreva M, Rangel-Moreno J, Netea MG, Barreiro LB, Divangahi M, Artyomov MN, Kaushal D, Khader SA.(2021) Lung Epithelial Signaling Mediates Early Vaccine-Induced CD4 + T Cell Activation and Mycobacterium tuberculosis Control. mBio. – mBio
Grieneisen L, Dasari M, Gould TJ, Björk JR, Grenier JC, Yotova V, Jansen D, Gottel N, Gordon JB, Learn NH, Gesquiere LR, Wango TL, Mututua RS, Warutere JK, Siodi L, Gilbert JA, Barreiro LB, Alberts SC, Tung J, Archie EA, Blekhman R. (2021) Gut microbiome heritability is nearly universal but environmentally contingent. Science. – Science
Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O’Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. (2021) Author correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. – Nat Immunol
Hawash MBF, Sanz-Remón J, Grenier JC, Kohn J, Yotova V, Johnson Z, Lanford RE, Brinkworth JF, Barreiro LB. (2021) Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity. Proc Natl Acad Sci. U.S.A – Proc Natl Acad Sci
Barreiro LB, Chervonsky A. (2021) My Old World chap, this α-gal is not for you. Cell Host Microbe. – Cell Host Microbe
Divangahi M, Aaby P, Khader SA, Barreiro LB, Bekkering S, Chavakis T, van Crevel R, Curtis N, DiNardo AR, Dominguez-Andres J, Duivenvoorden R, Fanucchi S, Fayad Z, Fuchs E, Hamon M, Jeffrey KL, Khan N, Joosten LAB, Kaufmann E, Latz E, Matarese G, van der Meer JWM, Mhlanga M, Moorlag SJCFM, Mulder WJM, Naik S, Novakovic B, O’Neill L, Ochando J, Ozato K, Riksen NP, Sauerwein R, Sherwood ER, Schlitzer A, Schultze JL, Sieweke MH, Benn CS, Stunnenberg H, Sun J, van de Veerdonk FL, Weis S, Williams DL, Xavier R, Netea MG. (2021) Trained immunity, tolerance, priming and differentiation: distinct immunological processes. Nat Immunol. – Nat Immunol
2020
Khan N, Downey J, Sanz J, Kaufmann E, Blankenhaus B, Pacis A, Pernet E, Ahmed E, Cardoso S, Nijnik A, Mazer B, Sassetti C, Behr MA, Soares MP, Barreiro LB, Divangahi M. (2020) M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity. Cell. – Cell
Randolph HE, Barreiro LB (2020) Herd Immunity: Understanding COVID-19. Immunity. – Immunity
Kim SM, DeFazio JR, Hyoju SK, Sangani K, Keskey R, Krezalek MA, Khodarev NN, Sangwan N, Christley S, Harris KG, Malik A, Zaborin A, Bouziat R, Ranoa DR, Wiegerinck M, Ernest JD, Shakhsheer BA, Fleming ID, Weichselbaum RR, Antonopoulos DA, Gilbert JA, Barreiro LB, Zaborina O, Jabri B, Alverdy JC (2020) Fecal microbiota transplant resues mice from human pathogen mediated sepsis by restoring systemic immunity. Nat Commun. – Nat Commun
Barreiro LB, Quintana-Murci L (2020) Evolutionary and population (epi)genetics of immunity to infection. Hum Genet. – Hum Genet
Sun S, Barreiro LB (2020) The epigenetically-encoded memory of the innate immune system. Curr Opin Immunol. – Curr Opin Immunol
Netea MG, Domínguez-Andrés J, Barreiro LB, Chavakis T, Divangahi M, Fuchs E, Joosten LAB, van der Meer JWM, Mhlanga MM, Mulder WJM, Riksen NP, Schlitzer A, Schultze JL, Stabell Benn C, Sun JC, Xavier RJ, Latz E. (2020) Defining trained immunity and its role in health and disease. Nat Rev Immunol. – Nat Rev Immunol
Abadie V, Kim SM, Lejeune T, Palanski BA, Ernest JD, Tastet O, Voisine J, Discepolo V, Marietta EV, Hawash MBF, Ciszewski C, Bouziat R, Panigrahi K, Horwath I, Zurenski MA, Lawrence I, Dumaine A, Yotova V, Grenier JC, Murray JA, Khosla C, Barreiro LB, Jabri B. (2020) IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease. Nature. – Nature
Ciszewski C, Discepolo V, Pacis A, Doerr N, Tastet O, Mayassi T, Maglio M, Basheer A, Al-Mawsawi LQ, Green PHR, Auricchio R, Troncone R, Waldmann TA, Azimi N, Tagaya Y, Barreiro LB, Jabri B (2020) Identification of a γc Receptor Antagonist That Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21. Gastroenterology. – Gastroenterology
2019
Sanz J, Maurizio PL, Snyder-Mackler N, Simons ND, Voyles T, Kohn J, Michopoulos V, Wilson M, Tung J, Barreiro LB (2019) Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques. Proc. Natl. Acad. Sci. U.S.A. – Proc. Natl. Acad. Sci
Lopez M, Choin J, Sikora M, Siddle K, Harmant C, Costa HA, Silvert M, Mouguiama-Daouda P, Hombert JM, Froment A, Le Bomin S, Perry GH, Barreiro LB, Bustamante CD, Verdu P, Patin E, Quintana-Murci L (2019) Genomic Evidence for Local Adaptation of Hunter-Gatherers to the African Rainforest. Curr Biol. – Curr Biol
Genelle F Harrison, Joaquin Sanz, Jonathan Boulais, Michael J Mina, Jean-Christophe Grenier, Yumei Leng, Anne Dumaine, Vania Yotova, Christina M Bergey, Stephen J Elledge, Erwin Schurr, Lluis Quitana-Murci, George H Perry, Luis B Barreiro (2019) Natural selection contributed to immunological differences between human hunter-gatherers and agriculturalists. Nat. Ecol. Evol. – Nat. Ecol. Evol.
Alain Pacis, Florence Mailhot-Leonard, Ludovic Tailleux, Haley E. Randolph, Vanya Yotova, Anne Dumaine, Jean-Christophe Grenier, Luis B. Barreiro (2018) Gene activation precedes DNA methylation in response to infection in human dendritic cells. Proc. Natl. Acad. Sci. U.S.A. – Proc. Natl. Acad. Sci
Snyder-Mackler N, Sanz J, Kohn JN, Voyles T, Pique-Regi R, Wilson ME, Barreiro LB, Tung J. (2019) Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques. Proc Natl Acad Sci USA. – Proc Natl Acad Sci USA
Lea AJ, Vockley CM, Johnston RA, Del Carpio CA, Barreiro LB, Reddy TE, Tung J. (2019) Genome-wide quantification of the effects of DNA methylation on human gene regulation. Elife. – Elife
Mayassi T, Ladell K, Gudjonson H, McLaren JE, Shaw DG, Tran MT, Rokicka JJ, Lawrence I, Grenier JC, van Unen V, Ciszewski C, Dimaano M, Sayegh HE, Kumar V, Wijmenga C, Green PHR, Gokhale R, Jericho H, Semrad CE, Guandalini S, Dinner AR, Kupfer SS, Reid HH, Barreiro LB, Rossjohn J, Price DA, Jabri B. (2019) Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease. Cell. – Cell
Lopez M, Choin J, Sikora M, Siddle K, Harmant C, Costa HA, Silvert M, Mouguiama-Daouda P, Hombert JM, Froment A, Le Bomin S, Perry GH, Barreiro LB, Bustamante CD, Verdu P, Patin E, Quintana-Murci L. (2019) Genomic Evidence for Local Adaptation of Hunter-Gatherers to the African Rainforest. Current Biology. – Current Biology
Sanz J, Maurizio PL, Snyder-Mackler N, Simons ND, Voyles T, Kohn J, Michopoulos V, Wilson M, Tung J*, Barreiro LB*. (2019) Social history and exposure to pathogen signals modulate social status effects on gene regulation in rhesus macaques. Proc Natl Acad Sci USA. *(co-senior and corresponding author) – Proc Natl Acad Sci USA.
2018
Lopez M, Kousathanas A, Quach H, Harmant C, Mouguiama-Daouda P, Hombert JM, Froment A, Perry GH, Barreiro LB, Verdu P, Patin E, Quintana-Murci L. (2018) The demographic history and mutational load of African hunter-gatherers and farmers. Nature Ecology and Evolution. – Nature Ecology and Evolution
Bergey CM, Lopez M, Harrisson GF, Patin E, Cohen JA, Quintana-Murci L, Barreiro LB, Perry GH (2018) Polygenic adaptation and convergent evolution on growth and cardiac genetic pathways in African and Asian rainforest hunter-gatherers. Proc. Natl. Acad. Sci. U.S.A. – Proc. Natl. Acad. Sci
Joaquin Sanz, Haley Randolph, Luis B. Barreiro (2018) Genetic and evolutionary determinants of human population variation in immune responses. Curr. Opin. Genet. Dev. – Curr. Opin. Genet. Dev.
Haley Randolph, Luis B. Barreiro (2018) Holy Immune Tolerance, Batman!. Immunity – Immunity
Marlies Meisel, Reinhard Hinterleitner, Alain Pacis, Li Chen, Zachary M. Earley, Toufic Mayassi, Joseph F. Pierre, Jordan D. Ernest, Heather J. Galipeau, Nikolaus Thuille, Romain Bouziat, Manuel Buscarlet, Daina L. Ringus, Yitang Wang, Ye Li, Vu Dinh, Sangman M. Kim, Benjamin D. McDonald, Matthew A. Zurenski, Mark W. Musch, Glaucia C. Furtado, Sergio A. Lira, Gottfried Baier, Eugene B. Chang, A. Murat Eren, Christopher R. Weber, Lambert Busque, Lucy A. Godley, Elena F. Verdú, Luis B. Barreiro & Bana Jabri (2018) Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature – Nature
Eva Kaufmann, Joaquin Sanz, Jonathan L. Dunn, Nargis Khan, Laura E. Mendonça, Alain Pacis, Fanny Tzelepis, Erwan Pernet, Anne Dumaine, Jean-Christophe Grenier, Florence Mailhot-Léonard, Eisha Ahmed, Jad Belle, Rickvinder Besla, Bruce Mazer, Irah L. King, Anastasia Nijnik, Clinton S. Robbins, Luis B. Barreiro and Maziar Divangahi (2018) BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis. Cell – Cell
2017
Jenny Tung, Luis B Barreiro (2017) The contribution of admixture to primate evolution. Current Opinion in Genetics & Development – Current Opinion in Genetics & Development
Kim-Hellmuth S, Bechheim M, Pütz B, Mohammadi P, Nédélec Y, Giangreco N, Becker J, Kaiser V, Fricker N, Beier E, Boor P, Castel SE, Nöthen MM, Barreiro LB, Pickrell JK, Müller-Myhsok B, Lappalainen T, Schumacher J, Hornung V. (2017) Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations. Nat Commun. – Nat Commun.
Manry J, Nédélec Y, Fava VM, Cobat A, Orlova M, Thuc NV, Thai VH, Laval G, Barreiro LB, Schurr E. (2017) Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation. PLoS Genet. – PLoS Genet.
Blischak JD, Tailleux L, Myrthil M, Charlois C, Bergot E, Dinh A, Morizot G, Chény O, Platen CV, Herrmann JL, Brosch R, Barreiro LB, Gilad Y. (2017) Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells. Sci Rep. – Sci Rep.
Gross JA, Pacis A, Chen GG, Drupals M, Lutz PE, Barreiro LB, Turecki G. (2017) Gene-body 5-hydroxymethylation is associated with gene expression changes in the prefrontal cortex of depressed individuals. Transl Psychiatry – Transl Psychiatry
Romain Bouziat, Reinhard Hinterleitner, Judy J. Brown, Jennifer E. Stencel-Baerenwald, Mine Ikizler, Toufic Mayassi, Marlies Meisel, Sangman M. Kim, Valentina Discepolo, Andrea J. Pruijssers, Jordan D. Ernest, Jason A. Iskarpatyoti, Léa M. M. Costes, Ian Lawrence, Brad A. Palanski, Mukund Varma, Matthew A. Zurenski, Solomiia Khomandiak, Nicole McAllister, Pavithra Aravamudhan, Karl W. Boehme, Fengling Hu, Janneke N. Samsom, Hans-Christian Reinecker, Sonia S. Kupfer, Stefano Guandalini, Carol E. Semrad, Valérie Abadie, Chaitan Khosla, Luis B. Barreiro, Ramnik J. Xavier, Aylwin Ng, Terence S. Dermody, Bana Jabri (2017) Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science – Science
Etienne Patin, Marie Lopez, Rebecca Grollemund, Paul Verdu, Christine Harmant, Hélène Quach, Guillaume Laval, George H. Perry, Luis B. Barreiro, Alain Froment, Evelyne Heyer, Achille Massougbodji, Cesar Fortes-Lima, Florence Migot-Nabias, Gil Bellis, Jean-Michel Dugoujon, Joana B. Pereira, Verónica Fernandes, Luisa Pereira, Lolke Van der Veen, Patrick Mouguiama-Daouda, Carlos D. Bustamante, Jean-Marie Hombert, Lluís Quintana-Murci (2017) Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America. Science – Science
2016
Aaron J. Sams, Anne Dumaine, Yohann Nédélec, Vania Yotova, Carolina Alfieri, Jerome E. Tanner, Philipp W. Messer and Luis B. Barreiro (2016) Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans. Genome Biol. – Genome Biol.
Natural Selection Kept Neanderthal DNA in Modern Humans – TheScientist
Snyder-Mackler N, Sanz J, Kohn JN, Brinkworth JF, Morrow S, Shaver AO, Grenier JC, Pique-Regi R, Johnson ZP, Wilson ME, Barreiro LB, Tung J. (2016) Social status alters immune regulation and response to infection in macaques. Science – Science
For Monkeys, Lower Status Affects Immune System – NY Times
Being popular is good for health – in monkeys, at least – New Scientist
Low social status ‘can damage immune system’ – BBC News
Le statut social se répercute sur le système immunitaire – ICI Radio-Canada
Le système immunitaire est influencé par le statut social – udemNouvelles
El ascenso en el estatus social hace a los monos más inmunes – Eco Diario
Wie der Sozialstatus das Immunsystem beeinflusst – Deutsche Apotheker Zeitung
Nédélec Y, Sanz J, Baharian G, Szpiech ZA, Pacis A, Dumaine A, Grenier JC, Freiman A, Sams AJ, Hebert S, Pagé Sabourin A, Luca F, Blekhman R, Hernandez RD, Pique-Regi R, Tung J, Yotova V, Barreiro LB. (2016) Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens. Cell – Cell
Neanderthal DNA affects ethnic differences in immune response – Nature
Africains et Européens ont des systèmes immunitaires génétiquement différents – Le Devoir
Des gènes néandertaliens derrière les différences ethniques dans la réponse immunitaire – La Presse
Richards AL, Burns MB, Alazizi A, Barreiro LB, Pique-Regi R, Blekhman R, Luca F. (2016) Genetic and transcriptional analysis of human host response to healthy gut microbiota. mSystems . – mSystems
Pai AA, Baharian G, Pagé Sabourin A, Brinkworth JF, Nédélec Y, Foley JW, Grenier JC, Siddle KJ, Dumaine A, Yotova V, Johnson ZP, Lanford RE, Burge CB, Barreiro LB. (2016) Widespread Shortening of 3′ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection. PLoS Genet . – PLoS Genet
Kohn JN, Snyder-Mackler N, Barreiro LB, Johnson ZP, Tung J, Wilson ME. (2016) Dominance rank causally affects personality and glucocorticoid regulation in female rhesus macaques. Psychoneuroendocrinology . – Psychoneuroendocrinology
Bouttier M, Laperriere D, Memari B, Mangiapane J, Fiore A, Mitchell E, Verway M, Behr MA, Sladek R, Barreiro LB, Mader S, White JH. (2016) Alu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection. Nucleic Acids Res . – Nucleic Acids Res
Blekhman R, Tang K, Archie EA, Barreiro LB, Johnson ZP, Wilson ME, Kohn J, Yuan ML, Gesquiere L, Grieneisen LE, Tung J. (2016) Common methods for fecal sample storage in field studies yield consistent signatures of individual identity in microbiome sequencing data. Sci Rep . – Sci Rep
Langlais D, Barreiro LB, Gros P. (2016) The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation. J Exp Med . – J Exp Med
Snyder-Mackler N, Kohn JN, Barreiro LB, Johnson ZP, Wilson ME, Tung J. (2016) Social status drives social relationships in groups of unrelated female rhesus macaques. Anim Behav . – Anim Behav
2015
Fagny M, Patin E, MacIsaac JL, Rotival M, Flutre T, Jones MJ, Siddle KJ, Quach H, Harmant C, McEwen LM, Froment A, Heyer E, Gessain A, Betsem E, Mouguiama-Daouda P, Hombert JM, Perry GH, Barreiro LB, Kobor MS, Quintana-Murci L. (2015) The epigenomic landscape of African rainforest hunter-gatherers and farmers. Nat Commun. – Nat Commun
Blischak JD, Tailleux L, Mitrano A, Barreiro LB, Gilad Y. (2015) Mycobacterial infection induces a specific human innate immune response. Sci Rep. – Sci Rep
Davenport ER, Cusanovich DA, Michelini K, Barreiro LB, Ober C, Gilad Y. (2015) Genome-Wide Association Studies of the Human Gut Microbiota. PLoS One. – PLoS One
Alain Pacis, Ludovic Tailleux, Alexander M Morin, John Lambourne, Julia L Maclsaac, Vania Yotova, Anne Dumaine, Anne Danckaert, Francesca Luca, Jean-Christophe Grenier, Kasper D Hansen, Brigitte Gicquel, Miao Yu, Athma Pai, Chuan He, Jenny Tung, Tomi Pastinen, Michael S Kobor, Roger Pique-Regi, Yoav Gilad and Luis B Barreiro. (2015) Bacterial infection remodels the DNA methylation landscape of human dendritic cells. Genome Res. – Genome Res
Cao M, Cortes M, Moore CS, Leong SY, Durosier LD, Burns P, Fecteau G, Desrochers A, Auer RN, Barreiro LB, Antel JP, Frasch MG. (2015) Fetal microglial phenotype in vitro carries memory of prior in vivo exposure to inflammation. Front Cell Neurosci. – Front Cell Neurosci
Jeffrey A. Gross, Alain Pacis, Gary G. Chen, Luis B. Barreiro, Carl Ernst and Gustavo Turecki. Characterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution. (2015) BMC Genomics. – BMC Genomics
Jenny Tung, Luis B Barreiro, Michael B Burns, Jean-Christophe Grenier, Josh Lynch, Laura E Grieneisen, Jeanne Altmann, Susan C Alberts, Ran Blekhman, Elizabeth A Archie. (2015) Social networks predict gut microbiome composition in wild baboons. eLife. – eLife
Fanny Tzelepis, Mark Verway, Jamal Daoud, Joshua Gillard, Kimya Hassani-Ardakani, Jonathan Dunn, Jeffrey Downey, Marilena Elena Gentile, Joanna Jaworska, Anthony Michel Jean Sanchez, Yohann Nédélec, Hojatollah Vali, Maryam Tabrizian, Arnold Scott Kristof, Irah Luther King, Luis Bruno Barreiro and Maziar Divangahi1. (2015) Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection. J Clin Invest. – JCI
Siddle KJ, Tailleux L, Deschamps M, Loh Y-HE, Deluen C, Gicquel B, Antoniewski C, Barreiro LB, Farinelli L, Quintana-Murci L. (2015) Bacterial Infection Drives the Expression Dynamics of microRNAs and Their isomiRs. PLoS Genet. – PLoS
Judith N. Mand, Rafi Ahmed, Luis B. Barreiro, Peter Daszak, Jonathan H. Epstein, Herbert W. Virgin, Mark B. Feinberg. (2015) Reservoir Host Immune Responses to Emerging Zoonotic Viruses.
Cell. – CellPress
2014
Brinkworth JF, Barreiro LB. (2014) The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease.
Current Opinion in Immunology. – PubMed
Perry GH, Foll M, Grenier JC, Patin E, Nédélec Y, Pacis A, Barakatt M, Gravel S, Zhou X, Nsobya SL, Excoffier L, Quintana-Murci L, Dominy NJ, Barreiro LB. (2014) Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.
Proc Natl Acad Sci U S A. – PNAS
Barreiro LB, Quintana-Murci L. (2014) Editorial Overview: Bringing evolution and genomics to human immunology. Current Opinion in Immunology. – ScienceDirect
Pacis A, Nédélec Y, Barreiro LB. (2014) When genetics meets epigenetics: deciphering the mechanisms controlling inter-individual variation in immune responses to infection. Current Opinion in Immunology. – ScienceDirect
Orbelyan GA, Tang F, Sally B, Solus J, Meresse B, Ciszewski C, Grenier JC, Barreiro LB, Lanier LL, Jabri B. (2014) Human NKG2E Is Expressed and Forms an Intracytoplasmic Complex with CD94 and DAP12. J Immunol. – PubMed
Lemay P, Knowler SP, Bouasker S, Nédélec Y, Platt S, Freeman C, Child G, Barreiro LB, Rouleau GA, Rusbridge C, Kibar Z. (2014) Quantitative Trait Loci (QTL) Study Identifies Novel Genomic Regions Associated to Chiari-Like Malformation in Griffon Bruxellois Dogs. PLoS One. – PubMed
Fagny M, Patin E, Enard D, Barreiro LB, Quintana-Murci L, Laval G. (2014) Exploring the Occurrence of Classic Selective Sweeps in Humans Using Whole-genome Sequencing Datasets. Mol Biol Evol. – PubMed
Dubois-Colas N, Petit-Jentreau L, Barreiro LB, Durand S, Soubigou G, Lecointe C, Klibi J, Rezaï K, Lokiec F, Coppée JY, Gicquel B, Tailleux L. (2014) Extracellular ATP affects the response of human macrophages infected with Mycobacterium tuberculosis. J Infect Dis. – PubMed
Davenport ER, Mizrahi-Man O, Michelini K, Barreiro LB, Ober C, Gilad Y. (2014) Seasonal variation in human gut microbiome composition. PLoS One. – PubMed
Siddle KJ, Deschamps M, Tailleux L, Nédélec Y, Pothlichet J, Lugo-Villarino G, Libri V, Gicquel B, Neyrolles O, Laval G, Patin E, Barreiro LB, Quintana-Murci L. (2014) A Genomic Portrait of the Genetic Architecture and Regulatory Impact of microRNA Expression in Response to Infection. Genome Research. – PubMed
Patin E, Siddle KJ, Laval G, Quach H, Harmant C, Becker N, Froment A, Régnault B, Lemée L, Gravel S, Hombert JM, Van der Veen L, Dominy NJ, Perry GH, Barreiro LB, Verdu P, Heyer E, Quintana-Murci L. (2014) The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists. Nature Communications. – Nature
2013
Grant AV, El Baghdadi J, Sabri A, El Azbaoui S, Alaoui-Tahiri K, Abderrahmani Rhorfi I, Gharbaoui Y, Abid A, Benkirane M, Raharimanga V, Richard V, Orlova M, Boland A, Migaud M, Okada S, Nolan DK, Bustamante J, Barreiro LB, Schurr E, Boisson-Dupuis S, Rasolofo V, Casanova JL, Abel L. (2013) Age-Dependent Association between Pulmonary Tuberculosis and Common TOX Variants in the 8q12-13 Linkage Region. Am J Hum Genet. 7;92(3):407-14 – PubMed
Quach H, Wilson D, Laval G, Patin E, Manry J, Guibert J, Barreiro LB, Nerrienet E, Verschoor E, Gessain A, Przeworski M, Quintana-Murci L. (2013) Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations. Hum Mol Genet. 1;22(23):4829-40 – PubMed
Orlova M, Cobat A, Huong NT, Ba NN, Van Thuc N, Spencer J, Nédélec Y, Barreiro L, Thai VH, Abel L, Alcaïs A, Schurr E. (2013) Gene set signature of reversal reaction type I in leprosy patients. PLoS Genet. 2013 Jul;9(7):e1003624 – PubMed
2012
Barreiro LB, Tung J (2012) Getting under—and through—the skin: ecological genomics of chytridiomycosis infection in frogs. Molecular Ecology 21(13):3095-7 – PubMed
Goyette G, Boulais J, Carruthers NJ, Landry CR, Jutras I, Duclos S, Dermine JF, Michnick SW, Laboissière S, Lajoie G, Barreiro L, Thibault P, Desjardins M (2012) Proteomic characterization of phagosomal membrane microdomains during phagolysosome biogenesis and evolution. Molecular Cell Proteomics – PubMed
Tung J, Barreiro LB, Johnson ZP, Hansen KD, Michopoulos V, Toufexis D, Michelini K, Wilson ME, Gilad Y (2012) Social environment is associated with gene regulatory variation in the rhesus macaque immune system. Proc Natl Acad Sci U S A 24;109(17):6490-5 – PubMed
Barreiro LB, Tailleux L, Marioni JC, BlekhmanR, Stephens S, Gicquel B, Gilad Y (2012) Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A 24;109(4):1204-9. – PubMed
2011
Manry J, Laval G, Patin E, Fornarino S, Itan Y, Fumagalli M, Sironi M, Tichit M, Bouchier C, Casanova JL, Barreiro LB, Quintana-Murci L. (2011) Evolutionary genetic dissection of human interferons. J Exp Med. 208(13):2747-59. – PubMed
Jabri B, Barreiro LB. (2011) Don’t move: LRRK2 arrests NFAT in the cytoplasm. Nat Immunol. 2011; 12(11): 1029-1030. – PubMed
Fornarino S, Barreiro LB, Manry J, Laval G, Quintana-Murci L. (2011) The evolution of TIR-domain-containing adaptors in humans: swinging between constraint and adaptation. Molecular Biology and Evolution. Mol Biol Evol. 2011; 28(11): 3087-3097. – PubMed
Manry J, Laval G, Patin E, Fornarino S, Tichit M, Bouchier C, Barreiro LB, Quintana-Murci L (2011) Evolutionary genetics evidence of an essential, non-redundant role of the IFN-γ pathway in protective immunity. Human Mutation. 32(6):633-42. – PubMed
Ben-Ali M, Corre B, Manry J, Barreiro LB, Quach H, Boniotto M, Pellegrini S, Quintana-Murci L (2011) Functional characterisation of naturally occurring genetic variants in the human TLR1-2-6 gene family. Human Mutation. 32(6):643-52. – PubMed
Abadie V, Sollid L, Barreiro LB*, Jabri B* (2011) Integration of genetic and immunological studies into a model of celiac disease pathogenesis. Annu Rev Immunol. 2011; 29: 493-525. – PubMed
2010
Barreiro LB, Marioni JC, BlekhmanR, Stephens S, Gilad Y (2010) Functional comparison of innate immune signaling pathways in primates. PLoS Genetics. Dec;6(12):e1001249 – PubMed
Quintana-Murci L, Barreiro LB. (2010) The role played by natural selection on Mendelian traits in humans. Annals of the New York Academy of Sciences. Dec; 1214:1 – 17. – PubMed
Laval G, Patin E, Barreiro LB, Quintana-Murci L. (2010) Formulating a historical and demographic model of recent human evolution based on resequencing data from noncoding regions. PLoS One. 22;5(4):e10284. – PubMed
2009
Barreiro LB & Quintana-Murci L. (2009) From evolutionary genetics to human immunology: how selection shapes host defence genes. Nature Reviews Genetics. 11(1):17-30 11(1):17-30. – PubMed
Ravel C, Chantot-Bastaraud S, Chalmey C, Barreiro L, Aknin-Seifer I, Pfeffer J, Berthaut I, Mathieu EE, Mandelbaum J, Siffroi JP, McElreavey K, Bashamboo A. (2009) Lack of association between genetic polymorphisms in enzymes associated with folate metabolism and unexplained reduced sperm counts. PLoS One. 4(8):e6540. – PubMed
Barreiro LB, Henriques R, Mhlanga MM. High-throughput SNP genotyping: combining tag SNPs and molecular beacons. Series: Methods in Molecular Biology, Vol. 578, 2009. – PubMed
Barreiro LB, Quach H, Patin E, Laval G, Bouchier C, Tichit M, Neyrolles O, Gicquel B, Kidd JR, Kidd KK, Alcaïs A, Abel L, Casanova JL, Quintana-Murci L (2009) Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense. PLoS Genetics 5(7):e1000562 – PubMed
Patin E, Laval G, Barreiro LB, Salas A, Semino O, Santachiara-Benerecetti S, Kidd KK, Kidd JR, Van der Veen L, Hombert JM, Gessain A, Froment A, Bahuchet S, Heyer E, Quintana-Murci L (2009) Inferring the demographic history of african farmers and pygmy hunter-gatherers using a multilocus resequencing data set. PLoS Genetics 5(4):e1000448 – PubMed
Quach H, Barreiro LB, Laval G, Zidane N, Patin E, Kidd KK, Kidd JR, Bouchier C, Veuille M, Antoniewski C, Quintana-Murci L (2009) Signatures of Purifying and Local Positive Selection in Human miRNAs. Am J Hum Genet 84(3):316-27 – PubMed
2008
Zhang J, Zhang X, Fu J, Bi Z, Arheart KL, Barreiro LB, Quintana-Murci L, Pahwa S, Liu H (2008) Protective role of DC-SIGN (CD209) neck-region alleles with <5 repeat units in HIV-1 transmission. J Infect Dis. 198(1):68-71. – PubMed
Barreiro LB*, Laval, G*, Quach H, Patin E, Quintana-Murci L (2008) Natural selection has driven population differentiation in modern humans. Nat Genet. 40(3):340-5.*These authors contributed equally to the work – PubMed
2007
Ben-Ali M, Barreiro LB, Chabbou A, Haltiti R, Braham E, Neyrolles O, Dellagi K, Gicquel B, Quintana-Murci L, Barbouche MR (2007) Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients. Hum Immunol. 68:908-912 – PubMed
Zhang SY, Jouanguy E, Ugolini S, Smahi A, Elain G, Romero P, Segal D, Sancho-Shimizu V, Lorenzo L, Puel A, Picard C, Chapgier A,Plancoulaine S, Titeux M, Cognet C, von Bernuth H, Ku CL, Casrouge A, Zhang XX, Barreiro LB, Leonard J, Hamilton C, Lebon P, Héron B, Vallée L, Quintana-Murci L, Hovnanian A, Rozenberg F, Vivier E, Geissmann F, Tardieu M, Abel L, and Casanova JL (2007) TLR3 Deficiency in Patients with Herpes Simplex Encephalitis. Science 5844:1522-1527 – PubMed
Barreiro LB, Neyrolles O, Babb CL, van Helden PD, Gicquel B, Hoal EG, Quintana-Murci L (2007) Length Variation of DC-SIGN and L-SIGN Neck-Region has no Impact on Tuberculosis Susceptibility. Hum Immunol. 68(2):106-112 – PubMed
Rosas-Magallanes V, Stadthagen-Gomez G, Rauzier J, Barreiro LB, Tailleux L, Boudou F, Griffin R, Nigou J, Jackson M, Gicquel B, Neyrolles (2007) Signature-Tagged Transposon Mutagenesis Identifies Novel Mycobacterium tuberculosis Genes Involved in the Parasitism of Human Macrophages. Infect Immun. 75:504-507 – PubMed
2006
Barreiro LB, Quintana-Murci L (2006) DC-SIGNR neck-region polymorphisms and HIV-1 susceptibility: From population stratification to a possible advantage of the 7/5 heterozygous genotype. J Infect Dis. 194:1184-1185 – PubMed
Verdu P*, Barreiro LB*, Patin E, Gessain A, Cassar O, Kidd JR, Kidd KK, Behar DM, Froment A, Heyer E, Sica L, Casanova JL, Abel L, Quintana-Murci L (2006) Evolutionary Insights into the High Worldwide Prevalence of MBL2 Deficiency Alleles. Hum Mol Genet. 15:2650-2658 *These authors contributed equally to the work – PubMed
Barreiro LB, Quach H Krahenbuhl J, Khaliq S, Mohyuddin A, Mehdi SQ Gicquel B Neyrolles O, Quintana-Murci L (2006) DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated to leprosy in the Pakistani population. Hum Immunol. 67:102-107 – PubMed
Barreiro LB, Neyrolles O, Babb C, Tailleux L, Quach H, McElreavey K, van Helden P, Hoal E, Gicquel B, Quintana-Murci L (2006) Promoter variation in the DC-SIGN encoding gene CD209 is associated with tuberculosis. PloS Med. 3(2) :e20 – PubMed
Patin E, Barreiro LB, Sabeti PC, Austerlitz F, Luca F, Sajantila A, Behar DM, Semino O, Sakuntabhai A, Guiso N, Gicquel B, McElreavey K, Harding RM, Heyer E, Quintana-Murci L (2006) Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes. Am J Hum Genet. 78:423-436 – PubMed
2005
Barreiro LB, Patin E, Neyrolles O, Cann HM, Gicquel B, Quintana-Murci L (2005) The heritage of pathogen pressures and ancient demography in the human innate immunity CD209/CD209L region. Am J Hum Genet. 77:869-886 – PubMed
2004
Portugal I, Barreiro LB, Moniz-Pereira J, Brum L. (2004) pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal. Antimicrob Agents Chemother 48:2736-2738 – PubMed