Publications

2017

Romain Bouziat, Reinhard Hinterleitner, Judy J. Brown, Jennifer E. Stencel-Baerenwald, Mine Ikizler, Toufic Mayassi, Marlies Meisel, Sangman M. Kim, Valentina Discepolo, Andrea J. Pruijssers, Jordan D. Ernest, Jason A. Iskarpatyoti, Léa M. M. Costes, Ian Lawrence, Brad A. Palanski, Mukund Varma, Matthew A. Zurenski, Solomiia Khomandiak, Nicole McAllister, Pavithra Aravamudhan, Karl W. Boehme, Fengling Hu, Janneke N. Samsom, Hans-Christian Reinecker, Sonia S. Kupfer, Stefano Guandalini, Carol E. Semrad, Valérie Abadie, Chaitan Khosla, Luis B. Barreiro, Ramnik J. Xavier, Aylwin Ng, Terence S. Dermody, Bana Jabri (2017) Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science – Science

Etienne Patin, Marie Lopez, Rebecca Grollemund, Paul Verdu, Christine Harmant, Hélène Quach, Guillaume Laval, George H. Perry, Luis B. Barreiro, Alain Froment, Evelyne Heyer, Achille Massougbodji, Cesar Fortes-Lima, Florence Migot-Nabias, Gil Bellis, Jean-Michel Dugoujon, Joana B. Pereira, Verónica Fernandes, Luisa Pereira, Lolke Van der Veen, Patrick Mouguiama-Daouda, Carlos D. Bustamante, Jean-Marie Hombert, Lluís Quintana-Murci (2017) Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America. Science – Science

2016

Aaron J. Sams, Anne Dumaine, Yohann Nédélec, Vania Yotova, Carolina Alfieri, Jerome E. Tanner, Philipp W. Messer and Luis B. Barreiro (2016) Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans. Genome Biol. Genome Biol.

Natural Selection Kept Neanderthal DNA in Modern Humans – TheScientist

Snyder-Mackler N, Sanz J, Kohn JN, Brinkworth JF, Morrow S, Shaver AO, Grenier JC, Pique-Regi R, Johnson ZP, Wilson ME, Barreiro LB, Tung J. (2016) Social status alters immune regulation and response to infection in macaques. Science Science

For Monkeys, Lower Status Affects Immune System – NY Times
Being popular is good for health – in monkeys, at least – New Scientist
Low social status ‘can damage immune system’ – BBC News
Le statut social se répercute sur le système immunitaire – ICI Radio-Canada
Le système immunitaire est influencé par le statut social – udemNouvelles
El ascenso en el estatus social hace a los monos más inmunes – Eco Diario
Wie der Sozialstatus das Immunsystem beeinflusst – Deutsche Apotheker Zeitung

Nédélec Y, Sanz J, Baharian G, Szpiech ZA, Pacis A, Dumaine A, Grenier JC, Freiman A, Sams AJ, Hebert S, Pagé Sabourin A, Luca F, Blekhman R, Hernandez RD, Pique-Regi R, Tung J, Yotova V, Barreiro LB. (2016) Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens. Cell Cell

Neanderthal DNA affects ethnic differences in immune response – Nature
Africains et Européens ont des systèmes immunitaires génétiquement différents – Le Devoir
Des gènes néandertaliens derrière les différences ethniques dans la réponse immunitaire – La Presse

Richards AL, Burns MB, Alazizi A, Barreiro LB, Pique-Regi R, Blekhman R, Luca F. (2016) Genetic and transcriptional analysis of human host response to healthy gut microbiota. mSystems . – mSystems

Pai AA, Baharian G, Pagé Sabourin A, Brinkworth JF, Nédélec Y, Foley JW, Grenier JC, Siddle KJ, Dumaine A, Yotova V, Johnson ZP, Lanford RE, Burge CB, Barreiro LB. (2016) Widespread Shortening of 3′ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection. PLoS Genet . – PLoS Genet

Kohn JN, Snyder-Mackler N, Barreiro LB, Johnson ZP, Tung J, Wilson ME. (2016) Dominance rank causally affects personality and glucocorticoid regulation in female rhesus macaques. Psychoneuroendocrinology . – Psychoneuroendocrinology

Bouttier M, Laperriere D, Memari B, Mangiapane J, Fiore A, Mitchell E, Verway M, Behr MA, Sladek R, Barreiro LB, Mader S, White JH. (2016) Alu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection. Nucleic Acids Res . – Nucleic Acids Res

Blekhman R, Tang K, Archie EA, Barreiro LB, Johnson ZP, Wilson ME, Kohn J, Yuan ML, Gesquiere L, Grieneisen LE, Tung J. (2016) Common methods for fecal sample storage in field studies yield consistent signatures of individual identity in microbiome sequencing data. Sci Rep . – Sci Rep

Langlais D, Barreiro LB, Gros P. (2016) The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation. J Exp Med . – J Exp Med

Snyder-Mackler N, Kohn JN, Barreiro LB, Johnson ZP, Wilson ME, Tung J. (2016) Social status drives social relationships in groups of unrelated female rhesus macaques. Anim Behav . – Anim Behav

2015

Fagny M, Patin E, MacIsaac JL, Rotival M, Flutre T, Jones MJ, Siddle KJ, Quach H, Harmant C, McEwen LM, Froment A, Heyer E, Gessain A, Betsem E, Mouguiama-Daouda P, Hombert JM, Perry GH, Barreiro LB, Kobor MS, Quintana-Murci L. (2015) The epigenomic landscape of African rainforest hunter-gatherers and farmers. Nat Commun. – Nat Commun

Blischak JD, Tailleux L, Mitrano A, Barreiro LB, Gilad Y. (2015) Mycobacterial infection induces a specific human innate immune response. Sci Rep. – Sci Rep

Davenport ER, Cusanovich DA, Michelini K, Barreiro LB, Ober C, Gilad Y. (2015) Genome-Wide Association Studies of the Human Gut Microbiota. PLoS One. – PLoS One

Alain Pacis, Ludovic Tailleux, Alexander M Morin, John Lambourne, Julia L Maclsaac, Vania Yotova, Anne Dumaine, Anne Danckaert, Francesca Luca, Jean-Christophe Grenier, Kasper D Hansen, Brigitte Gicquel, Miao Yu, Athma Pai, Chuan He, Jenny Tung, Tomi Pastinen, Michael S Kobor, Roger Pique-Regi, Yoav Gilad and Luis B Barreiro. (2015) Bacterial infection remodels the DNA methylation landscape of human dendritic cells. Genome Res. – Genome Res

Cao M, Cortes M, Moore CS, Leong SY, Durosier LD, Burns P, Fecteau G, Desrochers A, Auer RN, Barreiro LB, Antel JP, Frasch MG. (2015) Fetal microglial phenotype in vitro carries memory of prior in vivo exposure to inflammation. Front Cell Neurosci. – Front Cell Neurosci

Jeffrey A. Gross, Alain Pacis, Gary G. Chen, Luis B. Barreiro, Carl Ernst and Gustavo Turecki. Characterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution. (2015) BMC Genomics. – BMC Genomics

Jenny Tung, Luis B Barreiro, Michael B Burns, Jean-Christophe Grenier, Josh Lynch, Laura E Grieneisen, Jeanne Altmann, Susan C Alberts, Ran Blekhman, Elizabeth A Archie. (2015) Social networks predict gut microbiome composition in wild baboons. eLife. – eLife

Fanny Tzelepis, Mark Verway, Jamal Daoud, Joshua Gillard, Kimya Hassani-Ardakani, Jonathan Dunn, Jeffrey Downey, Marilena Elena Gentile, Joanna Jaworska, Anthony Michel Jean Sanchez, Yohann Nédélec, Hojatollah Vali, Maryam Tabrizian, Arnold Scott Kristof, Irah Luther King, Luis Bruno Barreiro and Maziar Divangahi1. (2015) Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection. J Clin Invest.JCI

Siddle KJ, Tailleux L, Deschamps M, Loh Y-HE, Deluen C, Gicquel B, Antoniewski C, Barreiro LB, Farinelli L, Quintana-Murci L. (2015) Bacterial Infection Drives the Expression Dynamics of microRNAs and Their isomiRs. PLoS Genet. – PLoS

Judith N. Mand, Rafi Ahmed, Luis B. Barreiro, Peter Daszak, Jonathan H. Epstein, Herbert W. Virgin, Mark B. Feinberg. (2015) Reservoir Host Immune Responses to Emerging Zoonotic Viruses.
Cell. – CellPress

2014

Brinkworth JF, Barreiro LB. (2014) The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease.
Current Opinion in Immunology. – PubMed

Perry GH, Foll M, Grenier JC, Patin E, Nédélec Y, Pacis A, Barakatt M, Gravel S, Zhou X, Nsobya SL, Excoffier L, Quintana-Murci L, Dominy NJ, Barreiro LB. (2014) Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.
Proc Natl Acad Sci U S A. – PNAS

Barreiro LB, Quintana-Murci L. (2014) Editorial Overview: Bringing evolution and genomics to human immunology. Current Opinion in Immunology. – ScienceDirect

Pacis A, Nédélec Y, Barreiro LB. (2014) When genetics meets epigenetics: deciphering the mechanisms controlling inter-individual variation in immune responses to infection. Current Opinion in Immunology.ScienceDirect

Orbelyan GA, Tang F, Sally B, Solus J, Meresse B, Ciszewski C, Grenier JC, Barreiro LB, Lanier LL, Jabri B. (2014) Human NKG2E Is Expressed and Forms an Intracytoplasmic Complex with CD94 and DAP12. J Immunol. – PubMed

Lemay P, Knowler SP, Bouasker S, Nédélec Y, Platt S, Freeman C, Child G, Barreiro LB, Rouleau GA, Rusbridge C, Kibar Z. (2014) Quantitative Trait Loci (QTL) Study Identifies Novel Genomic Regions Associated to Chiari-Like Malformation in Griffon Bruxellois Dogs. PLoS One.PubMed

Fagny M, Patin E, Enard D, Barreiro LB, Quintana-Murci L, Laval G. (2014) Exploring the Occurrence of Classic Selective Sweeps in Humans Using Whole-genome Sequencing Datasets. Mol Biol Evol. – PubMed

Dubois-Colas N, Petit-Jentreau L, Barreiro LB, Durand S, Soubigou G, Lecointe C, Klibi J, Rezaï K, Lokiec F, Coppée JY, Gicquel B, Tailleux L. (2014) Extracellular ATP affects the response of human macrophages infected with Mycobacterium tuberculosis. J Infect Dis.PubMed

Davenport ER, Mizrahi-Man O, Michelini K, Barreiro LB, Ober C, Gilad Y. (2014) Seasonal variation in human gut microbiome composition. PLoS One. – PubMed

Siddle KJ, Deschamps M, Tailleux L, Nédélec Y, Pothlichet J, Lugo-Villarino G, Libri V, Gicquel B, Neyrolles O, Laval G, Patin E, Barreiro LB, Quintana-Murci L. (2014) A Genomic Portrait of the Genetic Architecture and Regulatory Impact of microRNA Expression in Response to Infection. Genome Research. – PubMed

Patin E, Siddle KJ, Laval G, Quach H, Harmant C,  Becker N, Froment A, Régnault B, Lemée L, Gravel S, Hombert JM, Van der Veen L, Dominy NJ, Perry GH, Barreiro LB, Verdu P, Heyer E, Quintana-Murci L. (2014) The impact of agricultural emergence on the genetic history of African rainforest hunter-gatherers and agriculturalists. Nature Communications. – Nature

2013

Grant AV, El Baghdadi J, Sabri A, El Azbaoui S, Alaoui-Tahiri K, Abderrahmani Rhorfi I, Gharbaoui Y, Abid A, Benkirane M, Raharimanga V, Richard V, Orlova M, Boland A, Migaud M, Okada S, Nolan DK, Bustamante J, Barreiro LB, Schurr E, Boisson-Dupuis S, Rasolofo V, Casanova JL, Abel L. (2013) Age-Dependent Association between Pulmonary Tuberculosis and Common TOX Variants in the 8q12-13 Linkage Region. Am J Hum Genet. 7;92(3):407-14 – PubMed

Quach H, Wilson D, Laval G, Patin E, Manry J, Guibert J, Barreiro LB, Nerrienet E, Verschoor E, Gessain A, Przeworski M, Quintana-Murci L. (2013) Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations. Hum Mol Genet. 1;22(23):4829-40 – PubMed

Orlova M, Cobat A, Huong NT, Ba NN, Van Thuc N, Spencer J, Nédélec Y, Barreiro L, Thai VH, Abel L, Alcaïs A, Schurr E. (2013) Gene set signature of reversal reaction type I in leprosy patients. PLoS Genet. 2013 Jul;9(7):e1003624 – PubMed

2012

Barreiro LB, Tung J (2012) Getting under—and through—the skin: ecological genomics of chytridiomycosis infection in frogs. Molecular Ecology 21(13):3095-7 – PubMed

Goyette G, Boulais J, Carruthers NJ, Landry CR, Jutras I, Duclos S, Dermine JF, Michnick SW, Laboissière S, Lajoie G, Barreiro L, Thibault P, Desjardins M (2012) Proteomic characterization of phagosomal membrane microdomains during phagolysosome biogenesis and evolution. Molecular Cell Proteomics PubMed

Tung J, Barreiro LB, Johnson ZP, Hansen KD, Michopoulos V, Toufexis D, Michelini K, Wilson ME, Gilad Y (2012) Social environment is associated with gene regulatory variation in the rhesus macaque immune system. Proc Natl Acad Sci U S A 24;109(17):6490-5 – PubMed

Barreiro LB, Tailleux L, Marioni JC, BlekhmanR, Stephens S, Gicquel B, Gilad Y (2012) Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A 24;109(4):1204-9. – PubMed

2011

Manry J, Laval G, Patin E, Fornarino S, Itan Y, Fumagalli M, Sironi M, Tichit M, Bouchier C, Casanova JL, Barreiro LB, Quintana-Murci L. (2011) Evolutionary genetic dissection of human interferons. J Exp Med. 208(13):2747-59. – PubMed

Jabri B, Barreiro LB. (2011) Don’t move: LRRK2 arrests NFAT in the cytoplasm. Nat Immunol. 2011; 12(11): 1029-1030. – PubMed

Fornarino S, Barreiro LB, Manry J, Laval G, Quintana-Murci L. (2011) The evolution of TIR-domain-containing adaptors in humans: swinging between constraint and adaptation. Molecular Biology and Evolution. Mol Biol Evol. 2011; 28(11): 3087-3097. – PubMed

Manry J, Laval G, Patin E, Fornarino S, Tichit M, Bouchier C, Barreiro LB, Quintana-Murci L (2011)  Evolutionary genetics evidence of an essential, non-redundant role of the IFN-γ pathway in protective immunity. Human Mutation. 32(6):633-42. – PubMed

Ben-Ali M, Corre B, Manry J, Barreiro LB, Quach H, Boniotto M, Pellegrini S, Quintana-Murci L (2011) Functional characterisation of naturally occurring genetic variants in the human TLR1-2-6 gene family. Human Mutation. 32(6):643-52. – PubMed

Abadie V, Sollid L, Barreiro LB*, Jabri B* (2011) Integration of genetic and immunological studies into a model of celiac disease pathogenesis. Annu Rev Immunol. 2011; 29: 493-525. – PubMed

2010

Barreiro LB, Marioni JC, BlekhmanR, Stephens S, Gilad Y (2010) Functional comparison of innate immune signaling pathways in primates. PLoS Genetics. Dec;6(12):e1001249 – PubMed

Quintana-Murci L, Barreiro LB. (2010) The role played by natural selection on Mendelian traits in humans. Annals of the New York Academy of Sciences. Dec; 1214:1 – 17. – PubMed

Laval G, Patin E, Barreiro LB, Quintana-Murci L. (2010) Formulating a historical and demographic model of recent human evolution based on resequencing data from noncoding regions. PLoS One. 22;5(4):e10284. – PubMed

2009

Barreiro LB & Quintana-Murci L. (2009) From evolutionary genetics to human immunology: how selection shapes host defence genes. Nature Reviews Genetics. 11(1):17-30 11(1):17-30. – PubMed

Ravel C, Chantot-Bastaraud S, Chalmey C, Barreiro L, Aknin-Seifer I, Pfeffer J, Berthaut I, Mathieu EE, Mandelbaum J, Siffroi JP, McElreavey K, Bashamboo A. (2009) Lack of association between genetic polymorphisms in enzymes associated with folate metabolism and unexplained reduced sperm counts. PLoS One. 4(8):e6540. – PubMed

Barreiro LB, Henriques R, Mhlanga MM. High-throughput SNP genotyping: combining tag SNPs and molecular beacons. Series: Methods in Molecular Biology, Vol. 578, 2009. – PubMed

Barreiro LB, Quach H, Patin E, Laval G, Bouchier C, Tichit M, Neyrolles O, Gicquel B, Kidd JR, Kidd KK, Alcaïs A, Abel L, Casanova JL, Quintana-Murci L (2009) Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense. PLoS Genetics 5(7):e1000562 – PubMed

Patin E, Laval G, Barreiro LB, Salas A, Semino O, Santachiara-Benerecetti S, Kidd KK, Kidd JR, Van der Veen L, Hombert JM, Gessain A, Froment A, Bahuchet S, Heyer E, Quintana-Murci L (2009) Inferring the demographic history of african farmers and pygmy hunter-gatherers using a multilocus resequencing data set. PLoS Genetics 5(4):e1000448 – PubMed

Quach H, Barreiro LB, Laval G, Zidane N, Patin E, Kidd KK, Kidd JR, Bouchier C, Veuille M, Antoniewski C, Quintana-Murci L (2009) Signatures of Purifying and Local Positive Selection in Human miRNAs. Am J Hum Genet 84(3):316-27 – PubMed

2008

Zhang J, Zhang X, Fu J, Bi Z, Arheart KL, Barreiro LB, Quintana-Murci L, Pahwa S, Liu H (2008) Protective role of DC-SIGN (CD209) neck-region alleles with <5 repeat units in HIV-1 transmission. J Infect Dis. 198(1):68-71. – PubMed

Barreiro LB*, Laval, G*, Quach H, Patin E, Quintana-Murci L (2008) Natural selection has driven population differentiation in modern humans. Nat Genet. 40(3):340-5.*These authors contributed equally to the work – PubMed

2007

Ben-Ali M, Barreiro LB, Chabbou A, Haltiti R, Braham E, Neyrolles O, Dellagi K, Gicquel B, Quintana-Murci L, Barbouche MR (2007) Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients. Hum Immunol. 68:908-912 – PubMed

Zhang SY, Jouanguy E, Ugolini S, Smahi A, Elain G, Romero P, Segal D, Sancho-Shimizu V, Lorenzo L, Puel A, Picard C, Chapgier A,Plancoulaine S, Titeux M, Cognet C, von Bernuth H, Ku CL, Casrouge A, Zhang XX, Barreiro LB, Leonard J, Hamilton C, Lebon P, Héron B, Vallée L, Quintana-Murci L, Hovnanian A, Rozenberg F, Vivier E, Geissmann F, Tardieu M, Abel L, and Casanova JL (2007) TLR3 Deficiency in Patients with Herpes Simplex Encephalitis. Science 5844:1522-1527 – PubMed

Barreiro LB, Neyrolles O, Babb CL, van Helden PD, Gicquel B, Hoal EG, Quintana-Murci L (2007) Length Variation of DC-SIGN and L-SIGN Neck-Region has no Impact on Tuberculosis Susceptibility. Hum Immunol. 68(2):106-112 – PubMed

Rosas-Magallanes V, Stadthagen-Gomez G, Rauzier J, Barreiro LB, Tailleux L, Boudou F, Griffin R, Nigou J, Jackson M, Gicquel B, Neyrolles (2007) Signature-Tagged Transposon Mutagenesis Identifies Novel Mycobacterium tuberculosis Genes Involved in the Parasitism of Human Macrophages. Infect Immun. 75:504-507 – PubMed

2006

Barreiro LB, Quintana-Murci L (2006) DC-SIGNR neck-region polymorphisms and HIV-1 susceptibility: From population stratification to a possible advantage of the 7/5 heterozygous genotype. J Infect Dis. 194:1184-1185 – PubMed

Verdu P*, Barreiro LB*, Patin E, Gessain A, Cassar O, Kidd JR, Kidd KK, Behar DM, Froment A, Heyer E, Sica L, Casanova JL, Abel L, Quintana-Murci L (2006) Evolutionary Insights into the High Worldwide Prevalence of MBL2 Deficiency Alleles. Hum Mol Genet. 15:2650-2658 *These authors contributed equally to the work – PubMed

Barreiro LB, Quach H Krahenbuhl J, Khaliq S, Mohyuddin A, Mehdi SQ Gicquel B Neyrolles O, Quintana-Murci L (2006) DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated to leprosy in the Pakistani population. Hum Immunol67:102-107 – PubMed

Barreiro LB, Neyrolles O, Babb C, Tailleux L, Quach H, McElreavey K, van Helden P, Hoal E, Gicquel B, Quintana-Murci L (2006) Promoter variation in the DC-SIGN encoding gene CD209 is associated with tuberculosis. PloS Med. 3(2) :e20 – PubMed

Patin E, Barreiro LB, Sabeti PC, Austerlitz F, Luca F, Sajantila A, Behar DM, Semino O, Sakuntabhai A, Guiso N, Gicquel B, McElreavey K, Harding RM, Heyer E, Quintana-Murci L (2006) Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes. Am J Hum Genet. 78:423-436 – PubMed

2005

Barreiro LB, Patin E, Neyrolles O, Cann HM, Gicquel B, Quintana-Murci L (2005) The heritage of pathogen pressures and ancient demography in the human innate immunity CD209/CD209L region. Am J Hum Genet. 77:869-886 – PubMed

2004

Portugal I, Barreiro LB, Moniz-Pereira J, Brum L. (2004) pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal. Antimicrob Agents Chemother 48:2736-2738 – PubMed