The projects in our lab aim to better understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques (e.g., RNA-seq) with immunological and evolutionary genetic tools.
Feb 10 2017
The team section has a new look now on Mac/PC. Check it out, descriptions will come soon!
Jan 25 2017
Lab just came back from an incredible lab retreat! Plenty of ideas came out and that fresh air loaded up our batteries for this new year to come!
Nov 30 2016
New Neanderthal paper out!!! Check it out! Congrats Lab!
Nov 24 2016
Oct 20 2016
Genome-wide genetic data on ~500,000 UK Biobank participants biorxiv.org/content/early/…
Aaron J. Sams, Anne Dumaine, Yohann Nédélec, Vania Yotova, Carolina Alfieri, Jerome E. Tanner, Philipp W. Messer and Luis B. Barreiro (2016) Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans. Genome Biol. – Genome Biol.
Snyder-Mackler N, Sanz J, Kohn JN, Brinkworth JF, Morrow S, Shaver AO, Grenier JC, Pique-Regi R, Johnson ZP, Wilson ME, Barreiro LB, Tung J. (2016) Social status alters immune regulation and response to infection in macaques. Science – Science
Nédélec Y, Sanz J, Baharian G, Szpiech ZA, Pacis A, Dumaine A, Grenier JC, Freiman A, Sams AJ, Hebert S, Pagé Sabourin A, Luca F, Blekhman R, Hernandez RD, Pique-Regi R, Tung J, Yotova V, Barreiro LB. (2016) Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens. Cell – Cell
Pai AA, Baharian G, Pagé Sabourin A, Brinkworth JF, Nédélec Y, Foley JW, Grenier JC, Siddle KJ, Dumaine A, Yotova V, Johnson ZP, Lanford RE, Burge CB, Barreiro LB. (2016) Widespread Shortening of 3′ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection. PLoS Genet . – PLoS Genet
Alain Pacis, Ludovic Tailleux, Alexander M Morin, John Lambourne, Julia L Maclsaac, Vania Yotova, Anne Dumaine, Anne Danckaert, Francesca Luca, Jean-Christophe Grenier, Kasper D Hansen, Brigitte Gicquel, Miao Yu, Athma Pai, Chuan He, Jenny Tung, Tomi Pastinen, Michael S Kobor, Roger Pique-Regi, Yoav Gilad and Luis B Barreiro. (2015) Bacterial infection remodels the DNA methylation landscape of human dendritic cells. Genome Res. – Genome Res
Jenny Tung, Luis B Barreiro, Michael B Burns, Jean-Christophe Grenier, Josh Lynch, Laura E Grieneisen, Jeanne Altmann, Susan C Alberts, Ran Blekhman, Elizabeth A Archie. (2015) Social networks predict gut microbiome composition in wild baboons. eLife. – eLife
Perry GH, Foll M, Grenier JC, Patin E, Nédélec Y, Pacis A, Barakatt M, Gravel S, Zhou X, Nsobya SL, Excoffier L, Quintana-Murci L, Dominy NJ, Barreiro LB. (2014) Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.
Proc Natl Acad Sci U S A. – PNAS