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The projects in our lab aim to better understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques (e.g., RNA-seq) with immunological and evolutionary genetic tools.

News

Nov 30 2016
New Neanderthal paper out!!! Check it out! Congrats Lab!
Genome Biol.

Nov 24 2016

New paper out in Science! Great work with great collaborators! Thanks to the Tung lab for that amazing collaboration! Check it out, hot as it can be!
Our paper

Oct 20 2016

Our new paper is making the cover of Cell! An amazing long time effort by the lab! Check it out!
Cell, Volume 167, Issue 3
Our paper


Selected Publications

Aaron J. Sams, Anne Dumaine, Yohann Nédélec, Vania Yotova, Carolina Alfieri, Jerome E. Tanner, Philipp W. Messer and Luis B. Barreiro (2016) Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans. Genome Biol. Genome Biol.

Snyder-Mackler N, Sanz J, Kohn JN, Brinkworth JF, Morrow S, Shaver AO, Grenier JC, Pique-Regi R, Johnson ZP, Wilson ME, Barreiro LB, Tung J. (2016) Social status alters immune regulation and response to infection in macaques. Science Science

Nédélec Y, Sanz J, Baharian G, Szpiech ZA, Pacis A, Dumaine A, Grenier JC, Freiman A, Sams AJ, Hebert S, Pagé Sabourin A, Luca F, Blekhman R, Hernandez RD, Pique-Regi R, Tung J, Yotova V, Barreiro LB. (2016) Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens. Cell Cell

Pai AA, Baharian G, Pagé Sabourin A, Brinkworth JF, Nédélec Y, Foley JW, Grenier JC, Siddle KJ, Dumaine A, Yotova V, Johnson ZP, Lanford RE, Burge CB, Barreiro LB. (2016) Widespread Shortening of 3′ Untranslated Regions and Increased Exon Inclusion Are Evolutionarily Conserved Features of Innate Immune Responses to Infection. PLoS Genet . – PLoS Genet

Alain Pacis, Ludovic Tailleux, Alexander M Morin, John Lambourne, Julia L Maclsaac, Vania Yotova, Anne Dumaine, Anne Danckaert, Francesca Luca, Jean-Christophe Grenier, Kasper D Hansen, Brigitte Gicquel, Miao Yu, Athma Pai, Chuan He, Jenny Tung, Tomi Pastinen, Michael S Kobor, Roger Pique-Regi, Yoav Gilad and Luis B Barreiro. (2015) Bacterial infection remodels the DNA methylation landscape of human dendritic cells. Genome Res. – Genome Res

Jenny Tung, Luis B Barreiro, Michael B Burns, Jean-Christophe Grenier, Josh Lynch, Laura E Grieneisen, Jeanne Altmann, Susan C Alberts, Ran Blekhman, Elizabeth A Archie. (2015) Social networks predict gut microbiome composition in wild baboons. eLife. – eLife

Perry GH, Foll M, Grenier JC, Patin E, Nédélec Y, Pacis A, Barakatt M, Gravel S, Zhou X, Nsobya SL, Excoffier L, Quintana-Murci L, Dominy NJ, Barreiro LB. (2014) Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.
Proc Natl Acad Sci U S A. – PNAS